Peer-Reviewed Publications

Randomized controlled
trials against placebo Crossover comparisons
to standard of care medications Studies in various
specific sub-populations Large real-world
evidence (RWE) studies HEOR studies

Randomized controlled trials against placebo

Acute treatment, non-chronic adults

Acute treatment non-chronic adults – pivotal

Migraine prevention – chronic & episodic - pivotal

Temporal analysis of migraine prevention

Crossover comparisons to standard of care medications

Non-chronic adults - comparison to drugs

Adolescents - comparison to drugs

Chronic adults- comparison to drugs

Studies in various specific sub-populations

Adults with chronic migraine-TCH-005

Adults with chronic migraine-TCH-006

Adolescents - chronic and non-chronic

Children - Prospective Real-World Evidence Study

Women with menstrual migraine

Pregnant Women - retrospective controlled study

Treating migraine at school

Large real-world evidence (RWE) studies

Chronic & episodic adults (prospective RWE study)-RWE1

Chronic & episodic adults (prospective RWE study)-RWE2

Chronic & episodic adolescents (prospective RWE study)

Long-term treatment with REN (prospective RWE study)

Adolescents - Prevention benefits (prospective RWE study)

Combining REN with digital behavioral therapy - controlled RWE study

HEOR studies

Prospective OLE - reduction of acute migraine meds use when using REN

HEOR RCT - Savings to health plan when using REN for prevention

CED with a US payor (Highmark) - led to positive coverage decision

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