FAQs

Nerivio is indicated for acute and/or preventive treatment of migraine with or without aura in patients aged 12 and older. It is a self-administered device for use at home, both at the onset of migraine headache or aura for acute treatment and every other day for preventive treatment. In November 2024, the FDA approved the expanded age range for Nerivio, allowing use in children aged 8-11 for both acute and preventive treatment of migraines, with this clearance applicable only in the US.

This device should not be used by individuals with uncontrolled epilepsy or those with active implantable medical devices, such as a pacemaker, hearing aid implants, or any implanted electronic device. The device should only be applied to dry, healthy skin on the upper arm, with normal sensation and no metallic implants or proximity to cancerous lesions.

Note: The specific indications are subject to the approvals in the respective country/region. Please refer to the device box labeling for the regional indication.

Step 1: Install the "纳瑞维Nerivio" App

For Android devices: The Chinese version of the Nerivio app is now available and updated in the app stores of Huawei, OPPO, Vivo, Xiaomi, AppGallery, and the Meizu platform. Search for"纳瑞维Nerivio" and download it.

For iOS devices: Search for "纳瑞维Nerivio"in the App Store and download it.

Step 2: Connect the Device
To connect a new Nerivio device to the app, turn on the device (a slow flashing green light indicates the device is on) and press "Connect device" in the app. The first time you connect the Nerivio device to the app, it should be in no more than 1 inch away from your smartphone. Each device can only be associated with one user account.
If you have already connected the app to a specific Nerivio device, an automatic connection will be established once the device is turned on and the app is opened.

Nerivio will turn off automatically and has the following shut off features:

• The first time the device is turned on to pair and set up, the device will shut off automatically after 10 minutes.
• For all subsequent treatments, the device will give you 3 minutes to start the treatment and if not started, shuts off afterwards.
• If you pause the device during a treatment, the device will automatically shut off after 5 minutes if treatment is not restarted. Up to 3 treatment pauses can be used to ensure undisturbed treatment.
• At the end of any treatment the device will automatically turn off after one minute.

These built in timers will not impact the device’s ability to provide eighteen 45-minute treatments.

The armband should be wrapped around the device on your arm to improve the contact between the device and your skin. During your first use, you will need to adjust the armband to your size. There are 4 sizes you can choose from (S, M, L, XL). Use the extension for L and XL sizes.

The Nerivio app requires:

At least a 4.7-inch multi-touch screen, with a resolution of at least 720x1280 pixels

a CPU of 1GHz or faster, at least 2GB of internal memory, and at least 16GB of internal storage

with BT4.0 or above connectivity capability

Supported operating systems: iOS version 13 or newer and Android version 9 or newer

No, none of the materials we use contain latex.

Yes, our studies on acute treatment of migraine show that 66.7% of people experience pain relief within two hours of using Nerivio, and 37.4% achieve pain freedom within two hours post-treatment. Our studies on preventive treatment show that after two months of preventive treatment, the average reduction in migraine days per month is 4 days.

Acute treatment reference: https://doi.org/10.1111/head.13551
Preventive treatment reference: https://doi.org/10.1111/head.14469

Yes, treatments with Nerivio must be performed with the app connected via Bluetooth. Treatments with Nerivio do not require an internet connection, Wi-Fi, or mobile data. An internet connection is only needed when signing up or signing into the app. You should stay signed into the app when closing the app after a treatment, therefore internet will not be required for successive treatments.

Based on the Quick Start Guide included in the package, you can obtain the instructions, or contact the distributor for the User Manual.

The device is good for 18 (eighteen) 45-minute treatments, and once those treatments are completed, the device should be disposed according to the instructions.
To minimize moisture loss, when unused, the electrodes should be covered with the provided protective film and the device should be stored in its original package or in the travel bag. Also, every four treatments, rub the electrodes with your finger using a drop of water to improve their adhesiveness.

Nerivio works well both on its own and when used alongside prescribed medications. Combining it with other treatments may further enhance effectiveness. Please consult your doctor or healthcare professional to determine the best treatment plan for you.

The device transmits electrical pulses. You will need to set the treatment intensity level by increasing it to the highest level that feels strong yet comfortable and painless. You may feel a strong sensation at first, but it will typically fade to a comfortable level after a couple of seconds. If the sensation is uncomfortable or painful, you should decrease the intensity. During the treatment, you might experience a temporary sensation of warmth, local tingling, numbness in the arm, pain in the arm, or redness of the skin, which should disappear shortly after the end of the treatment. If you experience hand numbness and/or muscle twitching, try changing the location of the device on the arm.

For the best results with Nerivio, it is important to find the treatment intensity that is right for you. With each use, set the Nerivio intensity so that it feels strong but comfortable during the 45-minute session.

You can adjust the intensity in the app by tapping the ‘+’ and ‘-‘ buttons. Slowly increase the intensity to a point of discomfort, and then decrease it by 1%-2%. In clinical trials, intensities lower than 20% were found to be less effective.

There is no need to readjust the intensity during treatment, but if the stimulation sensation on your arm feels weak, you may increase it a little to bring it back to feel strong but not painful.

Nerivio can be used on either arm, regardless of the side of the headache.

Nerivio can be used to treat your migraines at any time. Our clinical data, however show that Nerivio is more effective when used right when the symptoms start, therefore it is recommended to start treatments with Nerivio within 60 minutes of the onset of aura or migraine headache. Nerivio can also be used for additional treatment sessions if the headache is not relieved or if it reoccurs. Please consult with your doctor for further instructions on use.

Nerivio can be used for both acute and preventative treatments.

Acute Treatment – Treating A Migraine Attack

• When needed
• 45 minutes treatment

Use Nerivio as often as needed to treat migraine attacks. For best treatment results, begin treatment as early as possible during a migraine attack.  

  Preventative Treatment – Treating for Migraine Prevention

• Every other day
• 45 minutes treatment

For migraine prevention therapy, treatment should be performed every other day. Treatments can be performed at any time during the day; the most important thing is to pick a time that is convenient for you and stick to it. The Nerivio app offers treatment reminders, so you never miss a treatment.

Combining Acute and Preventative Treatments

Nerivio can be used to prevent migraines and to treat migraine attacks as follows: use Nerivio every other day to prevent migraine and as needed to treat migraine attacks.

For example, if you choose to perform a preventative treatment every Monday, Wednesday, Friday, and Saturday and:

• If you have a migraine attack on one of the days in which you do not plan to perform preventative treatments (e.g., Sunday) – conduct a 45-minute treatment when your migraine attack starts. Then continue with your preventative treatment on Monday, Wednesday, Friday, and Saturday as usual.
• If you have a migraine attack on one of the days in which you are planned to perform a preventative treatment (e.g., Monday) – you can do one of the two: if you already preformed your preventive treatment and then had a migraine strike, you can perform another, acute treatment. There is no limit to the number of treatments per day you can perform. If you haven’t performed your preventive treatment yet, you can combine the treatments into one treatment (that means, perform an acute treatment which will also serve as your usual preventative treatment).  In either case, continue with your preventative treatment on Wednesday, Friday, and Saturday of this week as usual.
  

For preventive treatment, it is recommended to use Nerivio every other day to maintain treatment effectiveness. Irregular use may affect the consistency and reliability of the preventive effects.

There are differences in usage frequency. Acute treatment is used as needed, with each treatment lasting 45 minutes. Preventive treatment is done every other day, with each treatment also lasting 45 minutes. As for stimulation intensity, during both preventive and acute treatment, you need to adjust the intensity level to the highest level that feels "strong but comfortable and painless." Clinical trials found that intensities below 20% were less effective.

If there is no improvement or if the headache recurs after using Nerivio for acute treatment, you can perform additional treatments.

Make sure that the protective film was removed from the electrodes, that the device and the app are connected, and that the treatment has started and has not been stopped or paused. Set the treatment intensity level so it feels strong yet comfortable and painless by touching the ‘+’ button in the app. If the stimulation is still unfelt, it is possible that the electrodes are losing adhesion strength. With the device turned off, use your finger to gently rub one or two drops of water onto the gel surface of the electrodes to improve their adhesion. If the adhesive surface of the electrodes is damaged, you should replace the device.

Yes. Nerivio is a self-management device that can be used during migraine headache or aura, or for preventive treatment every other day. It is suitable for patients aged 12 and older with episodic or chronic migraines, with or without aura.

Nerivio and TENS units use different mechanism of actions, based on different electrical pulses and different stimulation sites.

Nerivio’s remote electrical neurostimulation (REN) mechanism is specifically designed to activate conditioned pain modulation, in which stimulation in the upper arm activates nerve endings that in turn activate a natural pain-relieving process in the brainstem, causing a global effect of pain inhibition that affects the original source of migraine pain in the head.

This differs from the mechanism of TENS units, which stimulate local nerves and compete with local pain fibers to block them from working (a mechanism termed gate theory), and thus must be applied at the same location of the pain (i.e., the head, during a migraine attack).

Two hours after acute treatment with Nerivio, 66.7% of patients experience pain relief, and 37.4% achieve pain freedom. At 48 hours after treatment, the pain relief and pain freedom rates are 39.1% and 20.7%, respectively, significantly higher than the placebo group. Nerivio is a well-tolerated acute migraine treatment with stable, consistent efficacy, and it can be used long-term.

Real-world clinical studies show that Nerivio is a safe, well-tolerated acute migraine treatment with stable, consistent efficacy over long-term use. In a 12-month study involving 409 patients, no serious device-related adverse events were reported, and mild/moderate events occurred in fewer than 2% of treatments. Importantly, there was no decline in therapeutic benefit: approximately 74% of users consistently experienced pain relief at two hours post-treatment, and 26% achieved pain freedom—with no signs of diminishing effectiveness over time.

Nerivio is drug-free and does not carry a risk of medication overuse, dependency, or systemic side effects. It is especially suitable for patients who cannot tolerate medication or have contraindications. Usage patterns remained stable throughout the year, indicating no signs of overuse or loss of response. Based on current data, Nerivio is appropriate for long-term use with no known long-term adverse effects.

参考： https://doi.org/10.1007/s12325-023-02697-6

Clinical data for migraine preventive treatment show that Nerivio begins to show significant preventive effects within 2 weeks. After two months of preventive treatment, the average reduction in migraine days per month is 4 days.

Nerivio can significantly relieve pain within 2 hours after treatment (from moderate or severe to none or mild, or from mild to none) and relieve the most distressing symptoms. Two hours after acute treatment with Nerivio, 66.7% of patients experience pain relief, and 37.4% achieve pain freedom. At 48 hours post-treatment, the pain relief and pain freedom rates are 39.1% and 20.7%, respectively, significantly higher than the placebo group.

Your privacy is very important to us, and your personal information will be securely stored. Your personal information will not be shared without your consent.

Yes! The Nerivio app supports multiple Nerivio devices used by the same user. You can use them with the same smartphone or different ones. This is how this is done:

1. Connect your first Nerivio to the app. The app is now paired with that device and you can control it using the app.
2. You can connect a different device using the app with the same user using the “Connect” button on the treatment screen. Note that you can only connect to one device at a time so make sure only one device is turned on and that no treatment is in progress.
3. You can have one Nerivio at home, another at work, and another to carry with you, if you so choose.
4. Note that using the same Nerivio device with different user accounts will not work.

You may contact the medical institution where you previously received your prescription or purchased Nerivio, or you can add our “Headache Management Consultant” on WeCom for assistance. Please insert the WeCom QR code here：

1. Licensed in Hainan Boao Lecheng:Nerivio has been approved for use in the Boao Lecheng International Medical Tourism Pilot Zone in Hainan. Clinical applications are available at Shanghai Jiaotong University Affiliated Ruijin Hospital Hainan Hospital and Hainan Medical University Affiliated First Hospital Lecheng Hospital (Ciming Boao International Hospital). Patients can contact "Migraine Management Consultant" for details.
2. Available in Hong Kong: Nerivio is now officially available in the Hong Kong market. You can contact "Migraine Management Consultant" for details.
3. Available in Mainland China: Nerivio will soon be fully launched in Mainland China. Eligible mainland patients can purchase it through cross-border channels for personal use. Please contact "Migraine Management Consultant" for more information or scan the purchase QR code below.